| Autor: |
Hawinkels, Lukas J. A. C., Verspaget, Hein W., van der Reijden, Johan J., van der Zon, Johanna M., Verheijen, Jan H., Hommes, Daniel W., Lamers, Cornelis B. H. W., Sier, Cornelis F. M. |
| Zdroj: |
Cancer Science; Apr2009, Vol. 100 Issue 4, p663-670, 8p, 2 Color Photographs, 1 Chart, 3 Graphs |
| Abstrakt: |
Transforming growth factor-β1 (TGF-β1), a cytokine involved in various stages of cancer, is produced as a latent complex and requires processing to become active. We have determined total and active TGF-β1 levels in homogenates of colorectal neoplasia. In contrast to total TGF-β levels, showing a stepwise increase in the mucosa-adenoma-carcinoma sequence, active TGF-β1 levels are increased only in carcinomas but not in premalignant adenomas. Furthermore, solely active TGF-β1 levels are associated with the stage of the carcinomas and worse patient prognosis. Active TGF-β1 levels correlated significantly with plasminogen activator inhibitor (PAI)-1, α-smooth muscle actin (SMA) and several matrix-remodeling proteinases. Interestingly, SMA levels are also significantly increased in colorectal carcinomas but not in adenomas, suggesting that despite the enhanced total TGF-β1 levels, myofibroblast accumulation is not (yet) occurring in these premalignant neoplasias. The correlation between active TGF-β1 and SMA expression in tumors indicates that tumor-promoting myofibroblasts might arise as a result of increased TGF-β1 activation. These data underline the significance of the interaction between malignant cells and (myo)-fibroblasts in the tumor microenvironment, modulating the biologic behavior of colorectal cancer. ( Cancer Sci 2009; 100: 663–670) [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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