Changes of Mitochondria and Relocation of the Apoptosis-Inducing Factor during Apoptosis.

Autor:	Scovassi, A. Ivana, Soldani, Cristiana, Veneroni, Paola, Bottone, Maria Grazia, Pellicciari, Carlo
Předmět:	APOPTOSIS MITOCHONDRIA ORGANELLES PROTOPLASM CHROMOSOMES
Zdroj:	Annals of the New York Academy of Sciences; Aug2009, Vol. 1171, p12-17, 6p, 1 Black and White Photograph, 1 Graph
Abstrakt:	During apoptosis, apoptosis-inducing factor (AIF) is released from the mitochondrial intermembrane space to the cytosol and to the nucleus. We analyzed AIF in HeLa cells driven to apoptosis by either etoposide or actinomycin D, and we observed changes in the structure and function of mitochondria as well as the translocation of cytochrome c and AIF from mitochondria to the nucleus in early apoptosis. In cells with fragmented chromatin (i.e., in late apoptosis), the immunolabeling for AIF appeared to be distinct from chromatin, being mainly confined to mitochondria. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.