UV-Derivative Spectrophotometric Determination of Ritonavir Capsules and Comparison with LC Method.

Autor:	Dias, CarolinaLupi, Bergold, AnaMaria, Fröehlich, PedroEduardo
Předmět:	PHARMACEUTICAL encapsulation SPECTROPHOTOMETRY LIQUID chromatography METHANOL GELATIN
Zdroj:	Analytical Letters; Aug2009, Vol. 42 Issue 12, p1900-1910, 11p, 1 Diagram, 3 Charts, 3 Graphs
Abstrakt:	An ultraviolet-derivative spectrophotometric method (UV-D) has been proposed as an alternative to a previously described liquid chromatographic (LC) method for the quantitative determination of ritonavir in soft gelatin capsules. The spectrophotometric method is based on recording the second-derivative spectra for ritonavir at 222.3 nm of its solutions in methanol. The linear dynamic range was 10.0-30.0 µg · mL-1 with a correlation coefficient of 0.9995. Mean recoveries were between 99.2% and 100.2% for the tested capsules samples. Mean intra- and interassay relative standard deviations (RSDs) were less than 2.0%. The statistic analysis showed that LC and UV-D methods were equivalent to assay ritonavir capsules. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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