A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction.

Autor: Clement, Karine, Vaisse, Christian, Lahlou, Najiba, Cabrol, Sylvie, Pelloux, Veronique, Cassuto, Dominique, Gourmelen, Micheline, Dina, Christian, Chambaz, Jean, Lacorte, Jean-Marc, Basdevant, Arnaud, Bougnères, Pierre, Lebouc, Yves, Froguel, Philippe, Guy-Grand, Bernard
Předmět:
Zdroj: Nature; 3/26/1998, Vol. 392 Issue 6674, p398, 4p, 5 Black and White Photographs, 2 Diagrams, 2 Charts, 3 Graphs
Abstrakt: Presents research which described a homozygous mutation in the human leptin receptor gene. Leptin's regulation of adipose-tissue mass; Leptin receptors; Homozygous mutations in genes encoding leptin in mice; Effects in humans of leptin deficiency due to mutation; Traits of such patients; Leptin's role in human endocrine functions.
Databáze: Complementary Index