Unmasking anti-endomysial antibodies in coeliac subjects positive for anti-smooth muscle antibodies.

Autor: Lasagni, D, Ferrari, R, Lapini, M
Předmět:
Zdroj: Acta Paediatrica; 04/15/19+H962799, Vol. 88 Issue 4, p462-464, 3p, 1 Chart
Abstrakt: Anti-endomysial antibodies assayed by indirect immunofluorescence presently represent the most advanced in vitro method for diagnosing coeliac disease. While testing the serum of patients affected by coeliac disease for anti-endomysial antibodies, we noticed in some samples the presence of anti-smooth muscle antibodies. This led us to the hypothesis that anti-smooth muscle antibodies might mask the presence of anti-endomysial antibodies. The aim of our research was to develop a method that could confirm our hypothesis. Here we show that the AEA response can be effectively unmasked by increasingly diluting anti-smooth muscle antibodies-positive serum.­. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index