Two decades of new concepts in nitric oxide signaling: From the discovery of a gas messenger to the mediation of nonenzymatic posttranslational modifications.

Autor: Martínez-Ruiz, Antonio, Lamas, Santiago
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Zdroj: IUBMB Life; Feb2009, Vol. 61 Issue 2, p91-98, 8p, 2 Diagrams
Abstrakt: For the past 20 years, nitric oxide (NO) has established itself as a gaseous free radical with crucial and unpredicted roles in a wide spectrum of biological functions and organisms. We present here a case whereby NO-mediated signaling can be broadly classified into classical (cGMP-mediated) and nonclassical, the latter mainly alluding to posttranslational modifications related to NO and its interaction with reactive groups in proteins. © 2008 IUBMB IUBMB Life, 61(2): 91–98, 2009 [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index