| Autor: |
Darko Kastelan, Tina Dusek, Ivana Kraljevic, Ozren Polasek, Zlatko Giljevic, Mirsala Solak, Silva Salek, Jozo Jelcic, Izet Aganovic, Mirko Korsic |
| Zdroj: |
Endocrine (1355008X); Aug2009, Vol. 36 Issue 1, p70-74, 5p |
| Abstrakt: |
Abstract Objective Hypercoagulability is a commonly described complication in patients with Cushing’s syndrome. Recent clinical studies have indicated various abnormalities of coagulation and fibrinolysis parameters which may be related to that phenomenon. The aim of this study was to investigate the mechanisms underlying the hypercoagulable state in patients with Cushing’s syndrome. Research methods and procedures A wide range of serum markers involved in the processes of blood coagulation and fibrinolysis was measured in a group of 33 patients with Cushing’s syndrome and 31 healthy controls. No participant was taking medication which could influence the result or had known diseases, except hypertension and diabetes, which could affect blood coagulation or fibrinolysis parameters. Results Patients with Cushing’s syndrome had higher levels of clotting factors II (P = 0.003), V (P P P P P = 0.019), protein C (P P P P = 0.004). The activity of fibrinolytic markers, plasminogen (P 0.001), antithrombin (P P = 0.001) was also increased in the patient group. Conclusion The study has demonstrated hypercoagulability in patients with Cushing’s syndrome manifest as increased prothrombotic activity and compensatory activation of the fibrinolytic system. We propose the introduction of thromboprophylaxis in the preoperative and early postoperative periods, combined with a close follow-up in order to prevent possible thromboembolic events in patients with Cushing’s syndrome. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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