Altered Integrin Mechanotransduction in Human Nucleus Pulposus Cells Derived From Degenerated Discs.

Autor:	Maitre, Christine Lyn Le, Frain, Jennie, Millward-Sadler, Jane, Fotheringham, Andrew P., Freemont, Anthony John, Hoyland, Judith Alison
Předmět:	INTEGRINS INTERVERTEBRAL disk CELL nuclei NEURODEGENERATION POLYMERASE chain reaction GLYCOPROTEINS MECHANOTHERAPY THERAPEUTICS
Zdroj:	Arthritis & Rheumatism; Feb2009, Vol. 60 Issue 2, p460-469, 10p, 2 Diagrams, 2 Charts, 2 Graphs
Abstrakt:	The article discusses the study which investigates the role of integrin signaling in intervertebral disc (IVD) cells during mechanical stimulation. It also determines the RGD integrins. The study explored human nucleus pulposus cells from nodegenerated and degenerated discs by real-time quantitative polymerase chain reaction (PRC). The findings indicate that the mechanotransduction altered in cells from degenerated IVD via RGD integrins from degenerated discs.
Databáze:	Complementary Index
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