Promoter Methylation of the Wnt/β-Catenin Signaling Antagonist Dkk-3 Is Associated With Poor Survival in Gastric Cancer.

Autor: Jun Yu, Qian Tao, Cheng, Yuen Y., Lee, Kwan Y., Ng, Simon S. M., Cheung, Kin F., Linwei Tian, Rha, Sun Y., Neumann, UIf, Röcken, Christoph, Ebert, Matthias P. A., Chan, Francis K. L., Sung, Joseph J. Y.
Předmět:
Zdroj: Cancer (0008543X); 1/1/2009, Vol. 115 Issue 1, p49-60, 12p
Abstrakt: The article presents a study examining the promoter methylation of the dickkopf homolog 3 gene (Dkk-3) and its significant role in digestive cancers. The study primarily investigates the prognostic implication of Dkk-3 methylation in patients with gastric cancer and colorectal cancer, evaluating as well the growth of the cancer cells. Details of the study are cited, indicating the common presence on the epigenetic silencing of the DKK-3 gene by promoter methylation in these cancer patients.
Databáze: Complementary Index