Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death.

Autor: Joza, Nicholas, Susin, Santos A., Daugas, Eric, Stanford, William L., Cho, Sarah K., Li, Carol Y.J., Sasaki, Takehiko, Ella, Andrew J., Cheng, H.-Y. Mary, Ravagnan, Luigi, Ferri, Karine F., Zamzami, Naoufal, Wakeham, Andrew, Hakem, Razqallah, Yoshida, Hiroki, Kong, Young-Yun, Mak, Tak W., Zuniga-Pflucker, Juan Carlos, Kroemer, Guido, Penninger, Josef M.
Předmět:
Zdroj: Nature; 3/29/2001, Vol. 410 Issue 6828, p549, 6p, 41 Color Photographs, 6 Black and White Photographs, 16 Graphs
Abstrakt: Shows that genetic inactivation of apoptosis-inducing factor (AIF) renders embryonic stem cells resistant to cell death after serum deprivation. Role of AIF in the programmed cell death during the cavitation of embryoid bodies; Role of programmed cell death in embryogenesis, organ metamorphosis and tissue homeostasis.
Databáze: Complementary Index