| Autor: |
Dudek, J., Benedix, J., Cappel, S., Greiner, M., Jalal, C., Müller, L., Zimmermann, R. |
| Předmět: |
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| Zdroj: |
Cellular & Molecular Life Sciences; May2009, Vol. 66 Issue 9, p1556-1569, 14p, 4 Diagrams, 1 Chart |
| Abstrakt: |
The endoplasmic reticulum (ER) is involved in a variety of essential and interconnected processes in human cells, including protein biogenesis, signal transduction, and calcium homeostasis. The central player in all these processes is the ER-lumenal polypeptide chain binding protein BiP that acts as a molecular chaperone. BiP belongs to the heat shock protein 70 (Hsp70) family and crucially depends on a number of interaction partners, including co-chaperones, nucleotide exchange factors, and signaling molecules. In the course of the last five years, several diseases have been linked to BiP and its interaction partners, such as a group of infectious diseases that are caused by Shigella toxin producing E. coli. Furthermore, the inherited diseases Marinesco-Sjögren syndrome, autosomal dominant polycystic liver disease, Wolcott-Rallison syndrome, and several cancer types can be considered BiP-related diseases. This review summarizes the physiological and pathophysiological characteristics of BiP and its interaction partners. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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