Antithrombogenic and Antiplatelet Activities of Extract from Maackia amyrensis Wood.

Autor:	A. Plotnikova, Z. Shulgau, T. Plotnikova, O. Aliev, N. Kulesh, N. Mischenko, S. Fedoreyev
Předmět:	ANTICOAGULANTS PLANT extracts WOOD chemistry THERAPEUTIC use of isoflavones VASODILATION LABORATORY rats OVARIECTOMY DRUG synergism
Zdroj:	Bulletin of Experimental Biology & Medicine; Feb2009, Vol. 147 Issue 2, p204-207, 4p
Abstrakt:	Antithrombogenic and antiplatelet effects of a new drug, containing isoflavonoids (extract from the wood of Maackia amyrensis, a Far Eastern plant), were studied. A course (200 mg/kg intragastrically during 14 days) of Maackia amyrensis extract prevented intravascular clotting, initiated by application of 10% iron chloride solution on the vessel. The drug increased antiaggregant activity of the vascular wall and potentiated endothelium-dependent vasodilatation in ovariectomied rats. The reference drug ethinylestradiol (25 μg/kg intragastrically during 14 days) potentiated the antiaggregant effect of the endothelium, but was inferior to Maackia amyrensis extract in the capacity to induce endothelium-dependent vasodilatation in ovariectomied rats. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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