Dose-finding Study of 153Sm-EDTMP in Patients With Poor-prognosis Osteosarcoma.

Autor: Loeb, David M., ElizabethvGarrett-Mayer, Hobbs, Robert F., Prideaux, Andrew P., Sgouros, George, Shokek, Ori, Wharam Jr., Moody D., Scott, Tammy, Schwartz, Cindy L.
Předmět:
Zdroj: Cancer (0008543X); 6/1/2009, Vol. 115 Issue 11, p2514-2522, 9p, 3 Charts, 4 Graphs
Abstrakt: The article presents a research which determined the maximal dose tolerance of Samarium-153 ethylendiaminetetramethylene phosphoric acid (Sm-DTMP) in treating patients with high-risk osteosarcoma. The result found that the maximally tolerated dose of Sm-DTMP is 44.8 megabecquerel. Furthermore, the data from the study support the development of future trials to assessing combined targeted radiotherapy and cytotoxic chemotherapy.
Databáze: Complementary Index