| Autor: |
Albani, Diego, Batelli, Sara, Polito, Letizia, Prato, Francesca, Pesaresi, Marzia, Gajo, Giovanni Battista, De Angeli, Sergio, Zanardo, Andrea, Galimberti, Daniela, Scarpini, Elio, Gallucci, Maurizio, Forloni, Gianluigi |
| Předmět: |
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| Zdroj: |
Age; Jun2009, Vol. 31 Issue 2, p155-162, 8p, 5 Charts, 2 Graphs |
| Abstrakt: |
The transcription rate of interleukin-6 (IL-6) can be reduced by the C-allele of a polymorphism (rs1800795) located in the 5′-flanking region of the IL-6 gene (NM_000600), and IL-6 plasma levels increase with age. We assembled an elderly Italian population [“The Treviso Longeva (Trelong) study”, age range 70–106 years, n = 668 subjects] and assessed rs1800795 genotype and plasma IL-6 concentrations. The rs1800795 genotype was also assessed in an independent Italian study (“Milan” study, age range 70–96, n = 245 subjects). To verify an age- or sex-specific effect of rs1800795 genotype we compared people younger (70–85) and older (85+) than 85 years of age. We found a significant reduction in the frequency of rs1800795 C/C genotype in 85+ men from the Trelong study, while in the Milan study this data did not reach significance. However, considering the two studies together, the frequency of the rs1800795 C/C genotype was significantly lower in 85+ than in 70–85 males (4.0% and 10.7%, respectively), while it remained unchanged in females. As for IL-6 plasma levels, after a multivariate analysis to control for confounders, a correlation between age and plasma IL-6 concentrations was revealed ( P < 0.0001). An increase in circulating IL-6 levels in the entire 85+ group compared to the 70–85 group ( P < 0.05, Tukey′s test) was also noticed. We suggest a sex-specific pattern for genetic variability linked to inflammatory response and longevity, consistent with the age-related increase in IL-6. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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