Electrochemical Behavior of Verapamil at Graphite-Polyurethane Composite Electrodes: Determination of Release Profiles in Pharmaceutical Samples.

Autor:	Semaan, FelipeS., Cavalheiro, ÉderT. G., Brett, ChristopherM. A.
Předmět:	ELECTROCHEMICAL analysis VERAPAMIL GRAPHITE POLYURETHANES ELECTRODES ELECTROLYTIC oxidation SPECTROPHOTOMETRY
Zdroj:	Analytical Letters; May2009, Vol. 42 Issue 8, p1119-1135, 17p, 1 Diagram, 3 Charts, 5 Graphs
Abstrakt:	A solid graphite-polyurethane composite electrode has been used to determine release profiles of verapamil, a calcium-channel blocker. The electro-oxidation process was characterized by cyclic voltammetry and electrochemical impedance spectroscopy and showed no adsorption of analyte or oxidation products, unlike at other carbon-based electrodes. Quantification gave linear ranges up to 40 µmol L-1 with cyclic voltammetry and detection limits of 0.7 µmol L-1 by differential pulse and square-wave voltammetry. Commercial product samples were successfully analyzed with results equal to those from spectrophotometry. Because no electrode surface renewal is needed, this electrode material has many advantages. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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