| Autor: |
Xi-Ji Shu, Hong-Yan Zhou, Wei Liu, Ying Chen, Cui-Lan Wang, Yan li, Qiong-Xia Chen, Li-Jiang Liu, Jian-Zhi Wang |
| Předmět: |
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| Zdroj: |
Neurochemical Research; Jul2009, Vol. 34 Issue 7, p1317-1323, 7p |
| Abstrakt: |
Abstract Granulocyte colony-stimulating factor (G-CSF) is a member of the cytokine family of growth factors that can protect the neurons from focal cerebral ischemia-induced injuries. The intracerebral hemorrhage (ICH) has been widely observed in the clinic; however, the protective effect of G-CSF on ICH is still elusive. We found in the present study that the intraperitoneal injection of G-CSF for 5 days could improve the ICH-induced neuronal behavioral impairment measured by limb placement assay. We also observed that injection of G-CSF could increase the number of stem cells in the specific zone of the hemorrhagic areas, demonstrated by the enhanced expression of nestin. Additionally, G-CSF could also promote the mobilization of circulating hemopoietic stem cells (HSCs) to the damaged brain areas and activate the astrocytes. Our results reveal that G-CSF is also protective for the ICH with the mechanisms involving proliferation of neural stem cells, the migration of HSCs and the activation of astrocytes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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