Use of Galleria mellonella larvae to evaluate the in vivo anti-fungal activity of [Ag2(mal)(phen)3].

Autor: Raymond Rowan, Ciara Moran, Malachy McCann, Kevin Kavanagh
Zdroj: BioMetals; Jun2009, Vol. 22 Issue 3, p461-467, 7p
Abstrakt: Abstract  Larvae of the insect Galleria mellonella were employed to assess the in vivo antifungal efficacy of ([Ag2(mal)(phen)3]), AgNO3 and 1,10-phenanthroline. Larvae pre-inoculated with these compounds were protected from a subsequent lethal infection by the yeast Candida albicans while larvae inoculated 1 and 4 h post-infection showed significantly increased survival (P G. mellonella larvae may be employed to ascertain the antifungal efficacy of silver(I) compounds and offers a rapid and effective means of assessing the in vivo activity of inorganic antimicrobial compounds. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index