| Autor: |
Sheng-Song Chen, Santomango, Tammy S., Williams, Phillip E., Lacy, D. Brooks, McGuinness, Owen P. |
| Předmět: |
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| Zdroj: |
American Journal of Physiology: Endocrinology & Metabolism; May2009, Vol. 296, pE1172-E1178, 7p, 2 Charts, 2 Graphs |
| Abstrakt: |
Glucose, fat, and glucagon availability are increased in diabetes. The normal response of the liver to chronic increases in glucose availability is to adapt to become a marked consumer of glucose. Yet this fails to occur in diabetes. The aim was to determine whether increased glucagon and lipid interact to impair the adaptation to increased glucose availability. Chronically catheterized well controlled depancreatized conscious dogs (n = 21) received 3 days of continuous parenteral nutrition (TPN) that was either high in glucose [C; 75% on protein calones (NPC)] or m hpld (HL; 75% NPC) in the presence or absence of a low dose (one-third basal) chronic intraportal infusion of glucagon (GN; 0.25 ng·kg-1·min-1). During the 3 days of TPN, all groups received the same insulin algorithm; the total amour/t of glucose infused (GIR) was varied to maintain isoglycemia (/120 mg/dl). On day 3 of TPN, hepatic metabolism was assessed. Glucose" and insulin levels were similar in all groups. GIR was decreased in HL and C GN (~30%) and was further decreased in HL + GN (55%). Net hepatic glucose uptake was decreased ~15% in C + GN, and HL and was decreased ~50% in HL + GN. Lipid alone or combined with glucagon decreased glucose uptake by peripheral tissues. Despite impairing whole body glucose utilization, HL did not limit whole body energy disposal. In contrast, glucagon suppressed whole blody energy disposal irrespective of the diet composition. In summary, failure to appropriately suppress glucagon secretion adds to the dietary fat-induced impairment in both hepatic and peripheral glucose disposal. In addition, unlike increasing the percentage of calories as fat, inappropriate glucagon secretion in the absence of compensatory hyperinsulinemia limits whole body nutrient disposition. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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