Mammalian Kinesin-3 Motors Are Dimeric In Vivo and Move by Processive Motility upon Release of Autoinhibition.

Autor: Hammond, Jennetta W., Cai, Dawen, Blasius, T. Lynne, Zhe Li, Yuyang Jiang, Gloria T. Jih, Edgar Meyhofer, Kristen J. Verhey
Předmět:
Zdroj: PLoS Biology; Mar2009, Vol. 7 Issue 3, pe1000072, 14p, 1 Color Photograph, 1 Chart, 5 Graphs
Abstrakt: This study defines the mechanisms of activation and motility of KIF1A motors, which drive the transport of presynaptic vesicles in neuronal cells, and suggests a simple model whereby cargo binding activates dimeric, autoinhibited motors. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index