| Autor: |
Nunes, Sandra, Figueiredo, Isabel, Soares, Paulo, Costa, Nuria, Lopes, Maria, Caramona, Maria |
| Předmět: |
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| Zdroj: |
Acta Diabetologica; Jun2009, Vol. 46 Issue 2, p135-140, 6p, 4 Charts |
| Abstrakt: |
The aim of this study was to evaluate the activity of semicarbazide-sensitive amine oxidase (SSAO) and the total nitrite and nitrate (NO x) concentrations in serum from type 2 diabetic patients and control subjects in order to evaluate if they could be used as novel diabetic markers. We studied 38 type 2 diabetic patients and 35 control subjects. Serum samples from those subjects were evaluated by radiochemical methods for SSAO activity using 14C-benzylamine. Serum NO x concentrations were obtained as an index of nitric oxide production by the Griess reaction. Serum SSAO activity was higher in type 2 diabetic patients than in control group and serum SSAO in type 2 diabetic correlated with age, serum creatinine and total cholesterol. Serum NO x levels in type 2 diabetic patients were also significantly higher than those in the control group. Serum NO x levels in control group correlated with serum SSAO activity. In conclusion, the increase in the SSAO activity and NO x levels observed in type 2 diabetic patients could be parameters to take in account and play relevant role in diabetes development. SSAO and NO x are suggested as markers for prognostic of diabetes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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