| Autor: |
Cao, Shugeng, Brodie, Peggy, Miller, James S., Birkinshaw, Chris, Rakotondrafara, A., Andriantsiferana, Rabodo, Rasamison, Vincent E., Kingston, David G.I. |
| Zdroj: |
Natural Product Research; May2009, Vol. 23 Issue 7, p638-643, 6p, 1 Diagram |
| Abstrakt: |
Bioassay-directed separation of an ethanol extract of the leaves of Helmiopsis sphaerocarpa L.C. Barnett (Sterculiaceae) led to the isolation of the new compound 14α,15α-epoxy-3β-hydroxytaraxerane (1) and the four known compounds taraxerol (2), stigmast-5-en-3-ol (3), 5α,8α-epidioxy-24(S)-methylcholesta-6,22-dien-3β-ol (4), and 24ξ-hydroperoxy-24-ethylcholesta-4,28(29)-dien-3-one (5). The structure of the new compound 1 was established on the basis of interpretation of its 1D and 2D NMR spectroscopic data. All the compounds were tested against A2780 human ovarian cancer cell lines, and compounds 4 and 5 showed mild antiproliferative activity, with IC50 values of 16 and 7 µg mL-1, respectively. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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