Association of the POLG1 T(−365)C, ANT1 G(−25)A, and PEO1 G(−605)T polymorphisms with diabetic polyneuropathy in patients with Type 1 diabetes mellitus.

Autor: Spitsina, E. V., Svetlova, G. N., Chudakova, D. A., Nikitin, A. G., Kurayeva, T. L., Strokov, I. A., Nosikov, V. V.
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Zdroj: Molecular Biology; Apr2009, Vol. 43 Issue 2, p348-352, 5p, 4 Charts
Abstrakt: This study is dedicated to a search for the association of the polymorphic markers T(−365)C of the POLG1 gene G(−25)A of the ANT1 gene and G(−605)T of the PEO1 gene with diabetic polyneuropathy (DPN) in Type 1 diabetes mellitus (DM1) patients. All patients were ethnic Russian Moscow residents, with DM1 records of no more than 5 years and DPN or DM1 records of more than 10 years but without DPN. We found that the polymorphic marker T(−365)C of POLG1 was associated with DPN in Russian patients with DM1. The carriers of the C allele and the CC genotype had a higher risk of DPN development (OR = 1.62; CI = 1.11–2.38; and OR = 1.76; CI = 0.99–3.13; respectively). In contrast, the T allele carrier status and the TT genotype were associated with a lower DPN risk (OR = 0.62, CI = 0.42–0.90; and OR = 0.61; CI = 0.35–1.07; respectively). We found no association of the polymorphic markers G(−25)A of ANT1 or G(−605)T of PEO1 with DPN in Russian DM1 patients living in Moscow. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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