| Autor: |
Wewers, Mary Ellen, Ahijevych, Karen L., Dhatt, Ravinder K., Guthrie, Robert M., Kuun, Patty, Mitchell, Lynn, Moeschberger, Melvin L., Chen, Moon S., Wewers, M E, Ahijevych, K L, Dhatt, R K, Guthrie, R M, Kuun, P, Mitchell, L, Moeschberger, M L, Chen, M S Jr |
| Předmět: |
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| Zdroj: |
Nicotine & Tobacco Research; Feb2000, Vol. 2 Issue 1, p85-91, 7p |
| Abstrakt: |
Understanding the contribution of race to factors associated with cigarette smoking and nicotine metabolism is essential for the characterization of patterns of tobacco use, nicotine dependence and incidence of tobacco-related diseases. This paper reports an investigation of cotinine levels among Southeast Asian smokers in two separate studies. Study 1 included 327 male and female smokers who participated in community-based interviews where smoking history information was obtained and a saliva continine sample was collected. Results indicated that subjects smoked an average of 11.2 cigarettes/day, with men reporting significantly higher consumption rates as compared to women (p < 0.0001). Subjects' mean cotinine level was 65 ng/ml with an average cotinine/cigarette ratio of 8.2. In Study 2, plasma and saliva cotinine in six Southeast Asian adult smokers were measured during 2 days of smoking followed by 6 days of abstinence. On day 1, mean plasma and saliva continine levels were 268 and 235 ng/ml, respectively. After 6 days of abstinence, mean levels had dropped to 12 ng/ml for plasma and 8 ng/ml in saliva. On average, it required at least 4.7 days for saliva continine levels to reach < 14 ng/ml. Mean cotinine concentrations during smoking differed in these two separate studies. Implications of these findings are discussed and future research recommendations are presented. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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