| Autor: |
Tsiklauri, L., Hoyer, H., Chkhikvadze, G., Vachnadze, V., Tsagareishvili, G., Bakuridze, A., Bernkop-Schnurch, A. |
| Předmět: |
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| Zdroj: |
Pharmaceutical Chemistry Journal; Dec2008, Vol. 42 Issue 12, p693-695, 3p, 2 Graphs |
| Abstrakt: |
The permeability of anti-arrhythmic crude alkaloids (Vingerbine preparation) from Vinca herbaceae W. et Kit. across rat intestine has been demonstrated for the first time. The results suggest that P-glycoproteins (P-gps) are involved in the preferential transport of vincarine and herbadine, compounds bearing a hydrogen atom on a secondary N (N―H), in the basolateral to apical direction. However, P-gp/MDR1 play a minor role in the intestinal transport of herbamine and vincamajine, compounds with substituted N (N―CH3). In order to improve peroral bioavailability and achieve maximum therapeutic efficiency of Vingerbine, further research will be focused on finding a strategy to overcome the P-gp barrier and developing suitable delivery systems. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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