| Autor: |
Fernandez-Funez, Pedro, Nino-Rosales, Maria Laura, de Gouyon, Beatrice, Wei-Chi She, Luchak, James M., Martinez, Pedro, Turiegano, Enrique, Benito, Jonathan, Capovilla, Maria, Skinner, Pamela J., McCall, Alanna, Canal, Inmaculada, Orr, Harry T., Zoghbi, Huda Y., Botas, Juan |
| Předmět: |
|
| Zdroj: |
Nature; 11/2/2000, Vol. 408 Issue 6808, p101, 6p, 26 Color Photographs, 23 Black and White Photographs, 2 Charts |
| Abstrakt: |
Presents a study which shows that high levels of wild-type ataxin-1 can cause degenerative phenotypes similar to those caused by the expanded protein. Genetic screens which were conducted to identify genes that modify spinocerebellar ataxia type 1-induced neurodegeneration; Findings, which may be relevant to the treatment of polyglutamine diseases and, perhaps, to other neurodegenerative diseases. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
