| Abstrakt: |
Five new amide alkaloids, N-(4-hydroxyphenethyl)octacosanamide ( 1), N-(4-hydroxyphenethyl)hexacosanamide ( 2), N-(4-hydroxyphenethyl)decanamide ( 3), N-vanilloyltyramine ( 4), and N-[ O-docosanoylvanilloyl]tyramine ( 5), were isolated from FAGARA MACROPHYLLA, together with 15 known compounds. Their structures were established by using spectroscopic techniques, chemical reactions, and comparison with previously known analogues. A cytotoxicity assay was performed with the isolates, in which compounds 4, 8, and 9 were found to possess moderate to weak activity, with IC 50values of 30.5, 11.5, and 13.5??g/mL, respectively. [ABSTRACT FROM AUTHOR] |
