| Autor: |
Matsuzaka, Takashi, Shimano, Hitoshi |
| Předmět: |
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| Zdroj: |
Journal of Molecular Medicine; Apr2009, Vol. 87 Issue 4, p379-384, 6p, 2 Diagrams |
| Abstrakt: |
Obesity is a major health problem in industrialized societies often associated with diabetes, insulin resistance, and hepatic steatosis. This review addresses the hypothesis that elongation of long-chain fatty acids family member 6 (Elovl6) has an important role in energy metabolism and insulin sensitivity. Elovl6 is a microsomal enzyme involved in the elongation of saturated and monounsaturated fatty acids with 12, 14, and 16 carbons. Mice with targeted disruption in the gene for Elovl6 ( Elovl6−/−) are resistant to diet-induced insulin resistance despite their hepatosteatosis and obesity being similar to that of the wild-type mice. Protection against diet-induced insulin resistance in Elovl6–/– mice is partially due to restoration of hepatic insulin receptor substrate-2 and suppression of hepatic protein kinase C ɛ, resulting in restoration of Akt phosphorylation. We suggest that inhibition of this elongase could be a new therapeutic approach for the treatment of insulin resistance, diabetes, cardiovascular disease, and other metabolic diseases. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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Full text from SpringerLink