| Autor: |
Bolitho, Paul, Street, Shayna E. A., Westwood, Jennifer A., Edelmann, Winfried, MacGregor, Duncan, Waring, Paul, Murray, William K., Godfrey, Dale I., Trapani, Joseph A., Johnstone, Ricky W., Smyth, Mark J. |
| Předmět: |
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| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; 2/24/2009, Vol. 106 Issue 8, p2723-2728, 6p, 3 Graphs |
| Abstrakt: |
In the present study, we have examined the effect of perform (pfp) deficiency in 4 models of mouse B-cell lymphomagenesis. We have examined pfp loss on the background of either Mlh1 tumor suppressor allele loss or oncogene expression [Ig heavy chain (Eμ)-v-Abl, Eμ-myc. and vav-bcl2]. Pfp was shown to act as a suppressor of B-cell malignancies characteristically driven by v-Abl or bcl-2, whereas Mlh loss cooperated in accelerating spontaneous B-cell lymphomas characteristic of pf p loss. No protective role for pfp was observed in the more aggressive Eμ-myc model of B-cell lymphoma. These transgenic models have allowed us to distinguish the role of pfp in surveillance of B-cell lymphomagenesis, as opposed to its loss simply driving the onset of a spontaneous lymphoma characteristic of pfp deficiency. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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