| Autor: |
da Silva, Rosali Maria Ferreira, de Medeiros, Flávia Patricia Morais, Nascimento, T. G., Macêdo, R. O., Neto, P. J. R. |
| Předmět: |
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| Zdroj: |
Journal of Thermal Analysis & Calorimetry; Mar2009, Vol. 95 Issue 3, p965-968, 4p, 1 Black and White Photograph, 2 Charts, 3 Graphs |
| Abstrakt: |
The object of the present work is to study the thermal characteristics of indinavir sulfate and to evaluate the quality of the raw materials. Indinavir A, B, C and reference samples were obtained from different suppliers and submitted to TG, DSC and DSC-photovisual analyses. TG/DTG curves indicated a desolvation and dehydration processes and were confirmed by DSC. According to the DSC curves the fusion took place at about 141–142°C for indinavir C and Reference sample B and about 146–149°C for the others. DSC-photovisual showed insoluble raw materials for indinavir C at 160°C. Indinavir sulfate is highly hygroscopic drug which requires attention during storage and manufacture by pharmaceutical industry. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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