Human immunodeficiency virus atropy induces modification of subcutaneous adipose tissue architecture: in vivo visualization by high-resolution magnetic resonance imaging.

Autor: Josse, G., Gensanne, D., Aquilina, C., Bernard, J., Saint-Martory, C., Lagarde, J. M., Schmitt, A. M.
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Zdroj: British Journal of Dermatology; Apr2009, Vol. 160 Issue 4, p741-746, 6p, 1 Black and White Photograph, 2 Charts, 4 Graphs
Abstrakt: Background Human immunodeficiency virus (HIV) infection generally induces lipodystrophy. For targeted treatment a better understanding of its development is necessary. The utility of high-resolution magnetic resonance imaging (MRI) is explored. Objectives The present study presents a way to visualize the adipose tissue architecture in vivo and to inspect modifications associated with the atrophy. Methods High-resolution MRI scans with surface coils were performed on the calf and at the lumbar region of three groups of patients: HIV patients with lipoatrophy, HIV patients without lipoatrophy and healthy volunteers. All patients underwent a clinical examination. In addition, dual energy X-ray absorptiometry (DEXA) measurements were taken. On the MRI scans adipose tissue thickness and adipose nodule size were measured. Results High-resolution MRI enabled identification of a clear disorganization of adipose tissue in patients with lipoatrophy. In addition, these patients presented a very small adipose tissue thickness on the calf and a very small nodule size. Results led to the hypothesis that adipose tissue disorganization appears before changes in DEXA measurements or clinically visible modifications. Conclusions High-resolution MRI enabled visualization in vivo of precise changes in tissue organization due to HIV lipoatrophy. This imaging technique should be very informative for better monitoring of the atrophy. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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