Relationship between adiponectin, inflammatory markers and obesity in Type 2 diabetic and non-diabetic Trinidadians.

Autor: Nayak, Shivananda, Soon, Stephanie Quan, Kunjal, Ryan, Ramadoo, Ria, Baptiste, Okera, Persad, Josann, Vandana Samodee, Temull, Vasant, Diptee, Leon, Balgobin, Sophia
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Zdroj: Archives of Physiology & Biochemistry; Feb2009, Vol. 115 Issue 1, p28-33, 6p, 2 Charts, 2 Graphs
Abstrakt: Aim: To determine and study the relationship between adiponectin and inflammatory markers in obese, non-obese, type 2 diabetic and non-diabetic Trinidadians. Methods: It was a cross-sectional study comprised of 133 subjects of Trinidadians. Anthropometric indices were measured and adiponectin, inflammatory marker levels, lipid profiles and glucose were measured in fasting blood samples. Results: Adiponectin levels were significantly lower (P = 0.003) in diabetics (n = 60) than non diabetics (n = 73). No correlation between adiponectin and inflammatory markers was found. Adiponectin levels were negatively correlated with BMI adjusting for age and diabetic status, and gender (β = -0.200, P = 0.020; β = -0.235, P = 0.004). Conclusions: No correlation exists between adiponectin and inflammatory markers. Adiponectin levels are lower in type 2 diabetic Trinidadians than in non-diabetics and decreases with increasing adiposity, using BMI as the marker. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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