Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling.
| Autor: | Herzog, Sebastian, Reth, Michael, Jumaa, Hassan |
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| Předmět: |
B cells
IMMUNOGLOBULINS GENETIC recombination CELL proliferation CELL differentiation CELLULAR mechanics TRANSCRIPTION factors PROTEIN metabolism RESEARCH GENETICS ANIMAL experimentation RESEARCH methodology CELL receptors MEDICAL cooperation EVALUATION research CELLULAR signal transduction CELL division COMPARATIVE studies HEMATOPOIESIS |
| Zdroj: | Nature Reviews Immunology; Mar2009, Vol. 9 Issue 3, p195-205, 11p, 4 Diagrams, 2 Charts |
| Abstrakt: | The pre-B-cell receptor (pre-BCR) is expressed following the productive recombination of the immunoglobulin heavy chain gene. Signals through the pre-BCR are required for initiating diverse processes in pre-B cells, including proliferation and recombination of the light chain gene, which eventually lead to the differentiation of pre-B cells to immature B cells. However, the molecular mechanisms by which the pre-BCR promotes these processes remain largely unresolved. Recent findings suggest that forkhead box O (FOXO) transcription factors connect pre-BCR signalling to the activation of the recombination machinery. In this Review, we discuss how FOXO transcription factors are regulated by the pre-BCR to allow the progression of the cell cycle and the recombination of the light chain gene. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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