Ceruloplasmin is a Better Predictor of the Long-Term Prognosis Compared With Fibrinogen, CRP, and IL-6 in Patients With Severe Unstable Angina.

Autor: Ziakas, Antonios, Gavrilidis, Stavros, Souliou, Efthimia, Giannoglou, George, Stiliadis, Ioannis, Karvounis, Haralambos, Efthimiadis, George, Mochlas, Sotirios, Vayona, M. Arvanitidou, Hatzitolios, Apostolos, Savopoulos, Christos, Pidonia, Ifigenia, Parharidis, George
Předmět:
Zdroj: Angiology; Feb/Mar2009, Vol. 60 Issue 1, p50-59, 10p
Abstrakt: Background. We investigated the time course and prognostic value of fibrinogen (Fib), C-reactive protein (CRP), interleukin-6 (IL-6), and ceruloplasmin (CP) in patients with severe unstable angina. Methods. All 4 substances were measured on admission and after 6, 12, 24, 48, and 72 hours, and after 7 days and 6 months in 40 patients with Braunwald's classification class IIIB unstable angina. Results. All recorded substances increased significantly; 15 patients had cardiovascular events during hospitalization and 11 patients during follow-up. The time course and the mean values of Fib, CRP, and IL-6 were similar in patients with and without complications both during hospitalization and follow-up. However, CP levels from 6 hours until 6 months were significantly higher in patients with complications during follow-up (P < .05). Conclusions. Fib, CRP, IL-6, and CP levels alter in patients with severe unstable angina. However, only CP levels were related to 12-month follow-up prognosis. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index