| Autor: |
NAGABABU, PENUMAKA, SHILPA, MYNAM, MUSTAFA, B., RAMJEE, P., SATYANARAYANA, S. |
| Předmět: |
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| Zdroj: |
Inorganic Reaction Mechanisms (De Gruyter); 2008, Vol. 6 Issue 4, p301-311, 11p, 1 Black and White Photograph, 1 Diagram, 1 Chart, 4 Graphs |
| Abstrakt: |
Four novel cobalt(III) and ruthenium(II) complexes [Ru(en)2(pyip)]2+ (1), [Ru(en)2+(aip)]2+ (2), [Co(en)2(pyip)]3+ (3) and [Co(en)2(aip)]3+ (4), (en=ethylenediamine, pyip =(pyip = 2-(1-pyrenyl)-1H-imidazo[4,5-f][1,10]phenanthroline), (aip = 2-(9-anthryl)-1H-imidazo[4,5,-f][1,10] phenanthroline) have been synthesized and characterized. The interaction of these complexes with calf thymus DNA was investigated using absorption (UV/vis) and emission spectroscopy, viscosity measurements as well as DNA melting and plasmid DNA cleavage studies. The experimental results show that the four complexes can bind to DNA in an intercalation mode. The DNA-binding affinity of complex 1 (Kb = 2.6 ± 0.3 x 1055 M-1) is greater than that of complexes 2, 3 and 4. Moreover, these four complexes have been found to promote the cleavage of plasmid DNA pBR322. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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