| Autor: |
Norbert Wendt, Angela Schulz, Fatimunnisa Qadri, Juliane Bolbrinker, Peter Kossmehl, Karl Winkler, Monika Stoll, Roland Vetter, Reinhold Kreutz |
| Předmět: |
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| Zdroj: |
Cardiovascular Research; Feb2009, Vol. 81 Issue 3, p618-618, 1p |
| Abstrakt: |
Aims Previously we confirmed an important role of rat chromosome 19 (RNO19) for salt-sensitive hypertension and target organ damage in male Dahl salt-sensitive rats (SS rats). The aim of this study was to further analyse the basis of left ventricular (LV) fibrosis development in both male and female rats in this model. To this end we utilized a consomic SS-19SHR rat strain in which RNO19 was transferred from spontaneously hypertensive rats (SHR) into the susceptible background of SS. Methods and results We compared the effects of low- (0.2% NaCl) and high-salt (4% NaCl) diet on the development of hypertension, blood lipids and LV fibrosis in male and female SS, SHR, and SS-19SHR rats. Systolic blood pressure was significantly lower in male and female SS-19SHR compared with SS under both diets (P P r = 0.464) and LVIF (r = 0.401, P Conclusion Our findings point to a link between hypercholesterolemia and LV fibrosis in salt-sensitive hypertension of SS rats which is genetically modulated by RNO19. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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