| Autor: |
Jeffery Babischkin, Thomas Bonagura, Laurence Udoff, Christine Vergara, Harry Johnson, Robert Atlas, Gerald Pepe, Eugene Albrecht |
| Zdroj: |
Endocrine (1355008X); Feb2009, Vol. 35 Issue 1, p81-88, 8p |
| Abstrakt: |
Abstract Vascular smooth muscle cell (VSMC) migration is a pivotal early step in blood vessel remodeling; however, very little is known about the regulation of this process in the human endometrium during the menstrual cycle. In this study, explants of human endometrium were incubated with estradiol and/or progesterone and the conditioned medium (CM) applied to cultures of VSMC to test the hypothesis that estrogen and progesterone stimulate endometrial cells to secrete a factor(s) that promotes VSMC migration. Endometrial explants were composed of highly organized glands and stroma. VSMC migration (cells migrated in 21 h/mm2 fibronectin-coated semipermeable membrane) in the presence of CM from human endometrial explants obtained in the proliferative phase of the menstrual cycle and incubated for 24 h with estradiol was approximately threefold greater (P P [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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