| Autor: |
Bastos, MF, Lima, JA, Vieira, PM, Mestnik, MJ, Faveri, M, Duarte, PM |
| Předmět: |
|
| Zdroj: |
Oral Diseases; Jan2009, Vol. 15 Issue 1, p82-87, 6p, 3 Charts, 1 Graph |
| Abstrakt: |
Objectives: The aim of this study was to evaluate tumor necrosis factor (TNF)-α and interleukin (IL)-4 levels in healthy sites and sites exhibiting signs of moderate and advanced generalized aggressive periodontitis (GAgP) in the same subject. Methods: The following sites were selected for crevicular fluid sampling in the same AgP subject ( n = 14): Healthy sites (HS): no marginal bleeding or bleeding on probing (BOP) and probing depth (PD) ≤ 3 mm; Moderate sites (MS): BOP and PD between 4 and 6 mm; Advanced sites (AS): BOP and PD ≥ 7 mm. One site from periodontally healthy subjects ( n = 13) was sampled for use as a control. TNF-α and IL-4 levels were measured using ELISA. Results: The total amount of TNF-α was lower for control sites, while there were no differences among healthy and diseased sites from GAgP subjects ( P < 0.05). The concentration of TNF-α was higher in HS, in relation to the other sites ( P < 0.05). There were no significant differences among the groups regarding total amounts of IL-4 ( P > 0.05), while IL-4 concentration was significantly higher in control sites, when compared with sites from GAgP subjects ( P < 0.05). Conclusion: In conclusion, high levels of TNF-α and low levels of IL-4 were observed in both healthy and diseased sites within the same generalized AgP individuals. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Plný text