| Autor: |
Sorokoumova, G. M., Vostrikov, V. V., Selishcheva, A. A., Rogozhkina, E. A., Kalashnikova, T. Yu., Shvets, V. I., Golyshevskaya, V. I., Martynova, L. P., Erokhin, V. V. |
| Předmět: |
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| Zdroj: |
Pharmaceutical Chemistry Journal; Aug2008, Vol. 42 Issue 8, p475-478, 4p, 1 Diagram, 2 Charts, 1 Graph |
| Abstrakt: |
Products of the decomposition and oxidation of rifampicin were obtained; characterized by spectrophotometry, TLC, and HPLC; and identified by mass spectrometry. The stability of the drug in aqueous solutions and in liposomal compositions at 4 and 25°C was evaluated. The main product of rifampicin decomposition on storage is 3-formylrifampicin SV. The antimicrobial activity of the antibiotic in liposomal compositions is the same as that in aqueous solutions and is well retained on storage. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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