| Autor: |
Iborra, R. T., Ribeiro, I. C. D., Neves, M. Q. T. S., Charf, A. M., Lottenberg, S. A., Negrão, C. E., Nakandakare, E. R., Passarelli, M. |
| Předmět: |
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| Zdroj: |
Scandinavian Journal of Medicine & Science in Sports; Dec2008, Vol. 18 Issue 6, p742-750, 9p, 3 Charts, 3 Graphs |
| Abstrakt: |
In this study, we analyzed the effect of aerobic exercise training (AET) and of a single bout of exercise on plasma oxidative stress and on antioxidant defenses in type 2 diabetes mellitus (DM) and in healthy control subjects (C). DM and C did not differ regarding triglycerides, high-density lipoprotein cholesterol (HDL-c), insulin, and HOMA index at baseline and after AET. To measure the lag time for low-density lipoprotein (LDL) oxidation (LAG) and the maximal rate of conjugated diene formation (MCD), participants' plasma HDL2 and HDL3 were incubated with LDL from pooled healthy donors' plasma. In the presence of HDL3, both LAG and MCD were similar in C and DM, but only in DM did AET improve LAG and reduce MCD. In the presence of HDL2, the lower baseline LAG in DM equaled C after AET. MCD was unchanged in DM after AET, but was lower than C only after AET. Furthermore, after AET plasma thiobarbituric acid-reactive substances were reduced only in DM subjects. Despite not modifying the total plasma antioxidant status and serum paraoxonase-1 activity in both groups, AET lowered the plasma lipid peroxides, corrected the HDL2, and improved the HDL3 antioxidant efficiency in DM independent of the changes in blood glucose, insulin, and plasma HDL concentration and composition. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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