| Autor: |
Garg, Jyoti, Anand, Kuljeet S., Nath, Manjeeta, Kanwar, Sumita |
| Předmět: |
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| Zdroj: |
Annals of Indian Academy of Neurology; Nov2008 Supplement, Vol. 11, pS133-S133, 1/3p |
| Abstrakt: |
Background: Distal sensory polyneuropathy is the most frequently reported type of human immunodeficiency virus (HIV)-infected patients. The risk factors associated with the development of sensory neuropathy include AIDS, alcohol abuse/dependence and antiretroviral medication use. Aim: The aim of this prospective study was to evaluate the incidence of HIV neuropathy, its character and correlation with duration of illness, antiretroviral medication and CD4 counts. Methods: HIV patients with symptoms of peripheral neuropathy referred from ART clinic, Dr RML Hospital (August 2006-March 08), were evaluated clinically and electro physiologically. Patients with evidence of vitamin B12 deficiency, alcohol intake and diabetes were excluded from the study. All patients underwent detailed neurological examination. Nerve conduction studies were performed in the upper limb and lower extremities. Chi square test was performed for observing difference in proportion between comparable groups. Results: Out of 39 patients 20 patients had HIV neuropathy. The mean duration of HIV and neuropathic symptoms was 2 yrs (<1 yr=6, >1yr=14) & 4 months respectively. CD4 cell counts were <200 in (17) and > 200 in (3). Clinical symptoms and sign of peripheral neuropathy were present in all .patients i.e. positive symptoms (16), negative symptoms (4), sensory deficit (11), and reflex loss (9). Nerve conduction studies were abnormal in 4 patients. The pattern of involvement is predominantly an axonal sensory motor neuropathy. Seventeen patients were on anti retroviral therapy (ART) (Three drug regimen). The proportion of patients with neuropathy was found to be significantly higher among those who received ART and in patients with CD4< 200 cells/ml (P<0.05). There was no significant difference in the presence of neuropathy in relation to duration of HIV. Conclusion: The present study reveals that significant number (50%) of patients with HIV showed clinical and electrophysiological evidence of sensory motor axonal neuropathy and the important predictors of neuropathy are the disease per se, low CD4 count and anti retroviral medication use. However there was no relation between HIV neuropathy and duration of illness in the present study. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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