| Autor: |
Semeikin, A. V., Levina, I. S., Kulikova, L. E., Kamernitskii, A. V., Vetchinkina, V. B., Atroshkin, K. A., Banin, V. V., Shimanovskii, N. L. |
| Předmět: |
|
| Zdroj: |
Pharmaceutical Chemistry Journal; May2008, Vol. 42 Issue 5, p258-261, 4p, 1 Diagram, 4 Charts |
| Abstrakt: |
The effects of six new steroids of the pregnane series, with substituents at the 16α, 17α, and-or 3 and 19 positions of the steroid skeleton, on the viability of cultured breast cancer MCF-7 and cervical cancer HeLa cells were studied. The results showed that 3-keto-4-dehydrosteroids with a 16α,17α-spiropentane substituent and 3-keto-4-dehydro-16α,17α-cyclohexanopregnanes with 3-or 19-oxyimino groups decreased the viability of both types of cell culture. These compounds had negative influences on the expression of the epidermal growth factor receptor (EGFR) and induced apoptosis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
