Use of the new levodopa agent Stalevo (levodopa/carbidopa/entacapone) in the treatment of Parkinson's disease in out-patient clinical practice (the START-M open trial).

Autor:	Boiko, A. N., Batysheva, T. T., Minaeva, N. G., Babina, L. A., Vdovichenko, T. V., Zhuravleva, E. Yu., Shikhkerimov, R. K., Malykhina, E. A., Khozova, A. A., Zaitsev, K. A., Kostenko, E. V.
Předmět:	DOPA PARKINSON'S disease treatment MOVEMENT disorders PHYSIOLOGY ENZYME inhibitors ENTACAPONE
Zdroj:	Neuroscience & Behavioral Physiology; Nov2008, Vol. 38 Issue 9, p933-936, 4p, 2 Charts, 1 Graph
Abstrakt:	Despite the significant symptomatic effects of levodopa, stable 24-h treatment responses are in the vast majority of patients replaced 2–3 years from the start of treatment by oscillations in motor symptoms (fluctuation, dyskinesia), amelioration of which requires addition of constant (physiological) stimulation of postsynaptic dopamine receptors. To some extent this is provided by Stalevo, which contains levodopa and two enzyme inhibitors: the DDC inhibitor carbidopa and the COMT inhibitor entacapone. The results obtained in the present study demonstrated the advantages of Stalevo over traditional agents in patients with the “wearing off” and “on-off” phenomena. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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