| Autor: |
Davis, A. M., Harris, B. J., Lien, E. L., Pramuk, K., Trabulsi, J. |
| Předmět: |
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| Zdroj: |
European Journal of Clinical Nutrition; Nov2008, Vol. 62 Issue 11, p1294-1301, 8p, 4 Charts, 3 Graphs |
| Abstrakt: |
Objective:To evaluate the efficacy and safety of an α-lactalbumin-enriched formula with a protein profile and total protein concentration closer to human milk (HM) and lower than conventional formulas.Subjects/methods:Two hundred and sixteen healthy, term infants, 14 days post-natal age were enrolled and 166 (76.9%) completed the study. Timed post-prandial plasma essential amino-acid levels were determined after 8 weeks of ad libitum study feeding. Study events were assessed every 2 weeks.Results:At 8 weeks, all mean plasma essential amino-acid levels in the experimental formula (EF) group were as high as the standard formula (SF) and HM groups. The incidence of feeding-related gastrointestinal (GI) events varied significantly (P=0.025) across groups: SF (31.3%), EF (17.2%) and HM (13.6%), with SF being significantly higher than HM (P=0.015). Study withdrawals due to feeding-related GI events were significantly different (P=0.001) across groups: SF (12.5%), EF (4.7%), and HM (0%). The timing of GI events was also significantly different across groups (P=0.010).Conclusion:The study demonstrated that feeding a higher quality, lower protein concentration formula (α-lactalbumin-enriched) met all essential amino acid and protein requirements of infants. The GI tolerance profile of infants receiving the EF was similar to HM-fed infants.European Journal of Clinical Nutrition (2008) 62, 1294–1301; doi:10.1038/sj.ejcn.1602848; published online 25 July 2007 [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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