Accuracy of quantitative coronary angiography with computed tomography and its dependency on plaque composition.

Autor: Lars Husmann, Oliver Gaemperli, Tiziano Schepis, Hans Scheffel, Ines Valenta, Tobias Hoefflinghaus, Paul Stolzmann, Lotus Desbiolles, Bernhard Herzog, Sebastian Leschka, Borut Marincek, Hatem Alkadhi
Zdroj: International Journal of Cardiovascular Imaging; Dec2008, Vol. 24 Issue 8, p895-904, 10p
Abstrakt: Abstract   Objective: To determine the impact of plaque composition on accuracy of quantitative 64-slice computed tomography coronary angiography (CTCA). Methods: The institutional review board approved this study; written informed consent was obtained from all patients. One hundred consecutive patients (42 women, mean age 64.6 ± 9.4 years, age range 39–87 years) underwent CTCA and invasive quantitative coronary angiography (QCA) to determine (a) the diagnostic accuracy of CTCA for the detection of significant stenosis (diameter reduction of ≥50%), and (b) the accuracy of stenosis grading. In CTCA stenosis severity was graded in 10% steps and evaluated separately for calcified and non-calcified coronary lesions using Pearson-linear-regression analysis, Bland/Altman-analysis (BA), and Mann-Whitney-U-test. Results: In 60/100 patients 139 significant coronary artery stenoses were identified with QCA. On a per-segment analysis, sensitivity of CTCA was 75.5%, and specificity was 96.6% (positive predictive value: 72.9%, negative predictive value: 97.0%). Quantification of stenosis grading correlated moderately between methods (r = 0.60; P P Conclusions: Diagnostic accuracy of CTCA is high, however agreement for quantitative lesion severity assessment between CTCA and QCA is moderate for calcified but superior for non-calcified lesions. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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