| Autor: |
Di Somma, Salvatore, Magrini, Laura, Tabacco, Fabio, Marino, Rossella, Talucci, Veronica, Marrocco, Francesca, Cardelli, Patrizia, Ferri, Enrico, Pittoni, Valerio |
| Předmět: |
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| Zdroj: |
Congestive Heart Failure (15275299); Sep/Oct2008, Vol. 14 Issue 5, p245-250, 6p, 1 Chart, 3 Graphs |
| Abstrakt: |
Brain natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are currently used for the diagnosis, prognosis, and therapeutic decision making in heart failure patients. The aim of the study was to compare BNP and NT-proBNP plasma concentration profiles in 42 patients with decompensated heart failure who underwent treatment in the emergency department. A significant decrease in both peptide concentrations fell beyond 24 hours of therapy. BNP concentration underwent a more responsive change from admission (−54.1%±8.6% at 72 hours and −57.4%±7.6% at discharge) than NT-proBNP concentration (−17.6%±5.4% at 72 hours and −18.6%±5.6% at discharge). Although BNP and NT-proBNP concentrations were highly correlated, no correlation in their variations was found, a finding that suggests a different kinetic behavior in response to treatment. Sequential measurements of BNP and NT-proBNP provide a reliable marker to confirm clinical improvement after 24 hours of treatment. BNP may show some advantages over NT-proBNP as a more sensitive marker of early stabilization in response to therapy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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