| Autor: |
Suda, Toshio, Iwama, Atsushi, Hashiyama, Motohiro, Sakano, Seiji, Ohno, Mitsuharu |
| Předmět: |
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| Zdroj: |
Leukemia (08876924); Apr97 Supplement 3, Vol. 11, p451-453, 3p |
| Abstrakt: |
To analyze the molecular mechanisms or the proliferation and differentiation of hematopoietic cells, we have cloned PTKs from sorted stem cells. We discuss the expression and function of receptor tyrosine kinases, STK/RON, TIE, TEK and HTK which have been cloned from these cells. STK and its ligand, MSP contributed to the motility and phagocytosis of peritoneal macrophages and hone absorption of osleoelasts. Apoptosis was induced in an erythrorid cell line by the binding of MSP(MacrophageStimulating Protein). TIE, TEK and HTK were interestingly expressed in the subpopulations of stem cells and related to the myeloid differentiation. These study will indicate the heterogeneity of stem cells and their diverse differentiation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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