| Autor: |
O’Connor, Owen A., Portlock, Carol, Moskowitz, Craig, Straus, David, Hamlin, Paul, Stubblefield, Michael, Dumetrescu, Otila, Colevas, A. Dimitrios, Grant, Barbara, Zelenetz, Andrew |
| Předmět: |
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| Zdroj: |
British Journal of Haematology; Oct2008, Vol. 143 Issue 2, p201-209, 9p, 4 Charts |
| Abstrakt: |
The epothilones represent a novel group of microtubule stabilization agents that appear to retain activity even in chemotherapy-resistant cell lines and animal models. Because of their ability to overcome chemotherapy resistance, we conducted a phase II study of Ixabepilone in patients with indolent non-Hodgkin lymphoma and mantle cell lymphoma (MCL). Ixabepilone was given at a dose of 25 mg/m2 weekly for three of four consecutive weeks. Patients were required to have received ≤4 prior chemotherapy regimens, with an interval of at least one month since the last treatment, 3 months from prior rituximab, and 7 d from prior steroids, an absolute neutrophil count >1 × 109/l and a platelet count >50 × 109/l. Dose reductions were allowed. The overall response rate in assessable patients was 27% in this otherwise heavily treated population. One patient with chemotherapy-refractory follicular lymphoma attained a complete remission that lasted approximately 8 months. Three responses were also seen in refractory MCL and one in small lymphocytic lymphoma. The duration of response ranged from 2 to 8 months. Major toxicities included fatigue, myelosuppression and neuropathy. These data suggest that Ixabepilone has activity in chemotherapy-refractory lymphoma. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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