| Autor: |
Andreas Marx, Philipp Simon, Ronald Simon, Martina Mirlacher, Jakob Izbicki, Emre Yekebas, Jussuf Kaifi, Luigi Terracciano, Guido Sauter |
| Zdroj: |
Virchows Archiv: European Journal of Pathology; Sep2008, Vol. 453 Issue 3, p243-248, 6p |
| Abstrakt: |
Abstract Alpha-methylacyl-CoA racemase (AMACR) is an enzyme playing an important role in the β-oxidation of branched-chain fatty acids and fatty acid derivatives. Altered expression levels of AMACR have been described in various cancers including colorectal cancer (CRC). To determine the potential prognostic impact of AMACR expression, we analyzed 1,315 CRC on a tissue microarray (TMA) by immunohistochemistry (IHC). Clinical follow-up data were available from all cancer patients. Positive AMACR staining was observed in 1,074 (81.7%) of the 1,315 cases including 276 cancers with weak (21.0%) and 798 cancers with strong staining (60.7%). AMACR IHC was significantly associated with tumor grade, stage, non-mucinous phenotype, and left-sided tumor localization (p p [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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