| Autor: |
O'Connor, Brian P., So-Young Eun, Zhengmao Ye, Zozuiya, Aila L., Lich, John D., Moore, Chris B., Iocca, Heather A., Roney, Kelly E., Holl, Eda K., Quing Ping Wu, Van Deventer, Hendrick W., Fabry, Zsuzsanna, Ting, Jenny P.-Y. |
| Předmět: |
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| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America; 9/2/2008, Vol. 105 Issue 35, p13015-13020, 6p, 5 Graphs |
| Abstrakt: |
The semaphorin and plexin family of ligand and receptor proteins provides important axon guidance cues required for development. Recent studies have expanded the role of semaphorins and plexins in the regulation of cardiac, circulatory and immune system function. Within the immune system. semaphorins and plexins regulate cell-cell interactions through a complex network of receptor and ligand pairs. Immune cells at different stages of development often express multiple semaphorins and plexins, leading to multivariate interactions, involving more than one ligand and receptor within each functional group. Because of this complexity, the significance of semaphorin and plexin regulation on individual immune cell types has yet to be fully appreciated. In this work, we examined the regulation of T cells by semaphorin 6D. Both in vitro and in vivo T cell stimulation enhanced semaphorin 6D expression. However, semaphorin 60 was only expressed by a majority of T cells during the late phases of activation. Consequently, the targeted disruption of semaphorin 60 receptor-ligand interactions inhibited T cell proliferation at late but not early phases of activation. This proliferation defect was associated with reduced linker of activated T cells protein phosphorylation, which may reflect semaphorin 60 regulation of c-Abl kinase activity. Semaphorin 6D disruption also inhibited expression of CD127, which is required during the multiphase antigen-presenting cell and T cell interactions leading to selection of long-lived lymphocytes. This work reveals a role for semaphorin 60 as a regulator of the late phase of primary immune responses. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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