Prooxidant–antioxidant balance, peroxide and catalase activity in the aqueous humour and serum of patients with exfoliation syndrome or exfoliative glaucoma.

Autor: George Koliakos, Christina Befani, Dimitrios Mikropoulos, Nikolaos Ziakas, Anastasios Konstas
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Zdroj: Graefe's Archive of Clinical & Experimental Ophthalmology; Oct2008, Vol. 246 Issue 10, p1477-1483, 7p
Abstrakt: Abstract Background  Oxidative stress plays an important role in the pathobiology of exfoliation syndrome (XFS) and exfoliative glaucoma (XFG). Methods  We investigated the prooxidant-antioxidant balance (PAB) in aqueous humour and serum samples of 20 consecutive cases of XFS, 20 of XFG, and 20 age-matched controls, employing a recently described novel assay. The activity of catalase and the levels of (hydrogen) peroxide were also measured in these samples. Results  There was no significant difference between the PAB in the aqueous humour of the XFS group (82.5 ± 10 AU) and age-matched control patients (78.9 ± 13.4 AU; p > 0.05). A significant shift of the PAB balance in favour of oxidants was detected in the XFG group (90.2 ± 7.6 AU) compared with controls (p  p p  Conclusions  These findings suggest that in XFS oxidative stress is counterbalanced in the aqueous, whereas the development of XFG is accompanied by a disruption of this balance in favour of oxidants. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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